US 421

 US Route 421 is a road that goes from US 20 in Michigan City, Indiana to a dead end at Fort Fisher, North Carolina. Since this is a Virginia-based website, this page will only have the Virginia part of the route.

The route in Virginia connects Pennington Gap to the Bristol Area, and for most of its time in the Commonwealth, US 421 is concurrent with US 58.

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VA-270

 Virginia State Route 270 is a short road that goes from VA-63 in St. Paul to US 58 also in St. Paul. The route is the main road serving the town and is one of the shortest Primary Routes in Virginia.

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VA-73

 Virginia State Route 73 is a short road that goes from US 1 northwest of Chamberlayne to I-95 still northwest of Chamberlayne. The route is a short connector between US 1 and I-95 and is part of the longer Parham Road, which goes from the north end of VA-150 to US 301/VA-2 just southwest of the Hanover/Henrico County Line.

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VA-160

 Virginia State Route 160 is a road that goes from KY-160 at the Virginia/Kentucky State Line to VA-68 in Appalachia. The route connects Cumberland and Lynch, KY to Appalachia and Wise County.

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